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Regio‐ and Stereoselective Oxidative Phenol Coupling in Aspergillus niger
Author(s) -
Gil Girol Christian,
Fisch Katja M.,
Heinekamp Thorsten,
Günther Stefan,
Hüttel Wolfgang,
Piel Jörn,
Brakhage Axel A.,
Müller Michael
Publication year - 2012
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201203603
Piecing it together : Aspergillus niger produces kotanin (see structure) by dimerization of the monomeric, polyketide‐synthase‐derived (PKS) 7‐demethylsiderin. A combined approach, comprising bioinformatics and gene‐deletion experiments, identified the biosynthetic cluster responsible for kotanin production. Homology modeling and substrate docking provide a rationale for the regio‐ and stereoselective phenol coupling reaction.