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Dual‐Function CXCR4 Antagonist Polyplexes To Deliver Gene Therapy and Inhibit Cancer Cell Invasion
Author(s) -
Li Jing,
Zhu Yu,
Hazeldine Stuart T.,
Li Chunying,
Oupický David
Publication year - 2012
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201203463
Subject(s) - dual function , cxcr4 antagonist , cxcr4 , cancer cell , function (biology) , cancer research , cancer therapy , cancer , genetic enhancement , chemotherapy , chemistry , gene , antagonist , dna , microbiology and biotechnology , biology , medicine , biochemistry , receptor , chemokine , contouring , engineering drawing , engineering
Giving a one‐two punch : A bicyclam‐based biodegradable polycation with CXCR4 antagonistic activity shows potential for combining cancer chemotherapy with gene therapy or siRNA therapy. This dual‐function polycation prevents cancer cell invasion by inhibiting CXCL12‐stimulated CXCR4 activation (see scheme), while at the same time efficiently and safely delivering therapeutic DNA into cancer cells.