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CO Cross‐Coupling of Activated Aryl and Heteroaryl Halides with Aliphatic Alcohols
Author(s) -
Maligres Peter E.,
Li Jing,
Krska Shane W.,
Schreier John D.,
Raheem Izzat T.
Publication year - 2012
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201203460
Subject(s) - aryl , halide , coupling (piping) , chemistry , medicinal chemistry , organic chemistry , materials science , alkyl , metallurgy
A robust and general catalyst system facilitates the alkoxylation of activated heteroaryl halides with primary, secondary, and select tertiary alcohols without the need for an excess of either coupling partner (see scheme). This catalyst system displays broad functional‐group tolerance and excellent regioselectivity, and is insensitive to the order of reagent addition.