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Solution Structure of a Parallel‐Stranded Oligoisoguanine DNA Pentaplex Formed by d(T(iG) 4 T) in the Presence of Cs + Ions
Author(s) -
Kang Mijeong,
Heuberger Ben,
Chaput John C.,
Switzer Christopher,
Feigon Juli
Publication year - 2012
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201203459
Subject(s) - alkali metal , ion , guanine , crystallography , group (periodic table) , chemistry , metal ions in aqueous solution , content (measure theory) , metal , physics , stereochemistry , mathematics , nucleotide , biochemistry , organic chemistry , mathematical analysis , gene
What a pentaplexing situation : Isoguanine (iG) is an isomer of guanine, where the positions of the C2 amino group and the C6 carboxy group are swapped. iG can self‐assemble into pentads in the presence of alkali metal cations. Cs + ions were found to stabilize a pentaplex of d(T(iG) 4 T). Solution NMR studies of this pentaplex in the presence of Cs + ions (or Na + , K + , Rb + , or NH 4 + cations) demonstrate its stability and structure (see picture).