N‐Heterocyclic Carbene Catalyzed Homoenolate‐Addition Reaction of Enals and Nitroalkenes: Asymmetric Synthesis of 5‐Carbon‐Synthon δ‐Nitroesters | Zendy

Maji Biswajit | Zendy; Ji Li | Zendy; Wang Siming | Zendy; Vedachalam Seenuvasan | Zendy; Ganguly Rakesh | Zendy; Liu XueWei | Zendy

Premium

N‐Heterocyclic Carbene Catalyzed Homoenolate‐Addition Reaction of Enals and Nitroalkenes: Asymmetric Synthesis of 5‐Carbon‐Synthon δ‐Nitroesters

Author(s) -

Maji Biswajit,

Ji Li,

Wang Siming,

Vedachalam Seenuvasan,

Ganguly Rakesh,

Liu XueWei

Publication year - 2012

Publication title -

angewandte chemie international edition

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 5.831

H-Index - 550

eISSN - 1521-3773

pISSN - 1433-7851

DOI - 10.1002/anie.201203449

Subject(s) - synthon , carbene , catalysis , enantioselective synthesis , chemistry , carbon fibers , combinatorial chemistry , organocatalysis , organic chemistry , materials science , composite number , composite material

Synthesizing synthons : The highly enantioselective title reaction is described. It employs catalytic amounts of N‐heterocyclic carbene precursors and transforms a broad range of nitroalkenes, such as nitrodienes, nitroenynes, and nitrostyrenes, through reaction with a broad range of enals, into δ‐nitroesters via homoenolate intermediates (see scheme).

This content is not available in your region!

Continue researching here.

Having issues? You can contact us here

Accelerating Research