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Access to Electron‐Rich Arene‐Fused Hexahydroquinolizinones through a Gold‐Catalysis‐Initiated Cascade Process
Author(s) -
Liu Lianzhu,
Zhang Liming
Publication year - 2012
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201203303
Subject(s) - cascade , alkyne , indole test , chemistry , catalysis , amide , nucleophile , combinatorial chemistry , cascade reaction , stereochemistry , organic chemistry , chromatography
Golden Cascade : With a tethered, electron‐rich arene as the internal nucleophile, a gold‐catalyzed amide cyclization to an alkyne initiates a cascade process that ends with a Ferrier rearrangement. Electron‐rich arene‐bearing hexahydroquinolizin‐2‐ones are formed in good yields and can be converted into indole alkaloids in only a few steps.