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CH Activation in S‐Alkenyl Sulfoximines: An Endo 1,5‐Hydrogen Migration
Author(s) -
Gao Xuefeng,
Gaddam Vikram,
Altenhofer Erich,
Tata Rama Rao,
Cai Zhengxin,
Yongpruksa Nattawut,
Garimallaprabhakaran Aswin K.,
Harmata Michael
Publication year - 2012
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201203258
Subject(s) - intramolecular force , hydride , chemistry , alkyl , redox , medicinal chemistry , class (philosophy) , combinatorial chemistry , hydrogen , stereochemistry , organic chemistry , computer science , artificial intelligence
Intramolecular redox reaction : Heating N‐alkyl, N‐allyl‐, and N‐benzyl‐substituted S‐alkenyl sulfoximines under appropriate conditions results in the formation of NH‐S‐alkyl sulfoximines. The intramolecular redox reaction involves a hydride transfer that occurs by a 6‐ endo ‐trig process. The intermediates in the reaction can also give access to four‐ and six‐membered heterocyclic rings and a new class of chiral dienes.