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Inside Cover: 6′′‐Thioether Tobramycin Analogues: Towards Selective Targeting of Bacterial Membranes (Angew. Chem. Int. Ed. 23/2012)
Author(s) -
Herzog Ido M.,
Green Keith D.,
BerkovZrihen Yifat,
Feldman Mark,
Vidavski Roee R.,
EldarBoock Anat,
SatchiFainaro Ronit,
Eldar Avigdor,
GarneauTsodikova Sylvie,
Fridman Micha
Publication year - 2012
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Reports
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201203240
Subject(s) - tobramycin , thioether , aminoglycoside , membrane , gentamicin , bacteria , amphiphile , chemistry , antibiotics , int , microbiology and biotechnology , combinatorial chemistry , biochemistry , biology , stereochemistry , organic chemistry , computer science , genetics , operating system , polymer , copolymer
Amphiphilic aminoglycoside antibiotics kill bacteria by disruption of their highly negatively charged membrane. In their Communication on page 5652 ff., M. Fridman, S. Garneau‐Tsodikova, and co‐workers report the synthesis of 6′′‐thioether tobramycin derivatives and show that their aliphatic chain acts as a drill bit that can rupture bacterial cells. These potent compounds evade many of the common bacterial resistance mechanisms, thereby opening a new avenue for the discovery of membrane‐targeting antibiotics.