Premium
Rhodium(III)‐Catalyzed Dehydrogenative Heck Reaction of Salicylaldehydes
Author(s) -
Shi Zhuangzhi,
Schröder Nils,
Glorius Frank
Publication year - 2012
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201203224
Subject(s) - aldehyde , chemistry , rhodium , flavones , heck reaction , catalysis , organic chemistry , combinatorial chemistry , palladium , chromatography
Your CHOice! An efficient Rh III ‐catalyzed dehydrogenative Heck reaction (DHR) of salicylaldehydes with different classes of olefins extends the oxidative Heck reaction to aldehyde CH bonds. Several structural motifs similar to natural products and bioactive molecules such as aurones, flavones, 2′‐hydroxychalcones, and flavanones could be efficiently produced. Initial mechanistic studies give insight into the reaction mechanism.