Hydrogen Peroxide Induced Activation of Gene Expression in Mammalian Cells using Boronate Estrone Derivatives | Zendy

Govan Jeane M. | Zendy; McIver Andrew L. | Zendy; Riggsbee Chad | Zendy; Deiters Alexander | Zendy

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Hydrogen Peroxide Induced Activation of Gene Expression in Mammalian Cells using Boronate Estrone Derivatives

Author(s) -

Govan Jeane M.,

McIver Andrew L.,

Riggsbee Chad,

Deiters Alexander

Publication year - 2012

Publication title -

angewandte chemie international edition

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 5.831

H-Index - 550

eISSN - 1521-3773

pISSN - 1433-7851

DOI - 10.1002/anie.201203222

Subject(s) - estrone , hydrogen peroxide , gene , gene expression , chemistry , estrogen , estrogen receptor , combinatorial chemistry , computational biology , biochemistry , biology , genetics , hormone , cancer , breast cancer

Keeping the boron out of the ER : A genetic switch was engineered that activates gene expression in the presence of H 2 O 2 (see scheme). The use of a boronate group on an estrone molecule allows for activation of gene expression through binding of the estrogen receptor only when the boron group is oxidized by H 2 O 2 . This sensor is highly sensitive and specific for H 2 O 2 .

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