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Highly Diastereo‐ and Enantioselective Cyclopropanation of 1,2‐Disubstituted Alkenes
Author(s) -
Li Jun,
Liao SaiHu,
Xiong Hu,
Zhou YouYun,
Sun XiuLi,
Zhang Yue,
Zhou XiaoGuang,
Tang Yong
Publication year - 2012
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201203218
Subject(s) - cyclopropanation , enantioselective synthesis , oxazoline , scheme (mathematics) , chemistry , information retrieval , series (stratigraphy) , stereochemistry , computer science , combinatorial chemistry , organic chemistry , catalysis , mathematics , biology , paleontology , mathematical analysis
A helping hand : A series of bis(oxazoline) ligands, which contain pendant C 2 ‐symmetry‐breaking groups, for the Cu‐catalyzed asymmetric cyclopropanation of 1,2‐disubstituted alkenes has been developed. Under mild reaction conditions, both cis ‐ and trans ‐1,2‐substituted alkenes can be converted into the corresponding 1,2,3‐trisubstituted cyclopropanes with high levels of diastereo‐ and enantioselectivity (see scheme).