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Hydrogels Incorporating GdDOTA: Towards Highly Efficient Dual T 1 /T 2 MRI Contrast Agents
Author(s) -
Courant Thomas,
Roullin Valérie Gaëlle,
Cadiou Cyril,
Callewaert Maïté,
Andry Marie Christine,
Portefaix Christophe,
Hoeffel Christine,
de Goltstein Marie Christine,
Port Marc,
Laurent Sophie,
Elst Luce Vander,
Muller Robert,
Molinari Michaël,
Chuburu Françoise
Publication year - 2012
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201203190
Subject(s) - gadolinium , nanoparticle , contrast (vision) , dual mode , relaxation (psychology) , dual (grammatical number) , computer science , chemistry , nanotechnology , materials science , philosophy , artificial intelligence , psychology , organic chemistry , engineering , neuroscience , aerospace engineering , linguistics
Do not tumble dry : Gadolinium‐DOTA encapsulated into polysaccharide nanoparticles (GdDOTA⊂NPs) exhibited high relaxivity ( r 1 =101.7 s −1 m M −1 per Gd 3+ ion at 37 °C and 20 MHz). This high relaxation rate is due to efficient Gd loading, reduced tumbling of the Gd complex, and the hydrogel nature of the nanoparticles. The efficacy of the nanoparticles as a T 1 / T 2 dual‐mode contrast agent was studied in C6 cells (see picture).