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Intramolecular CH Bond Activation through a Flexible Ester Linkage
Author(s) -
Shaffer Christopher J.,
Schröder Detlef,
Gütz Christoph,
Lützen Arne
Publication year - 2012
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201203163
Subject(s) - intramolecular force , linkage (software) , chemistry , transesterification , mass spectrometry , regioselectivity , ligand (biochemistry) , catalysis , catalytic cycle , combinatorial chemistry , stereochemistry , organic chemistry , chromatography , receptor , biochemistry , gene
Replacing the director : A bipyridinyl ligand with an aliphatic side chain determines the regioselectivity of copper‐catalyzed CH oxidation by intramolecular effects. Because the aliphatic chain is attached through an ester linkage, the catalytic cycle can in principle be closed by transesterification. Ion‐mobility mass spectrometry and isotopic labeling provide mechanistic insight not available from direct mass spectrometry experiments.