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Resveratrol Still Has Something To Say about Aging!
Author(s) -
Quideau Stéphane,
Deffieux Denis,
Pouységu Laurent
Publication year - 2012
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201203059
Subject(s) - resveratrol , sirtuin , sirtuin 1 , wine , phosphodiesterase , mechanism (biology) , polyphenol , chemistry , microbiology and biotechnology , enzyme , biochemistry , biology , food science , antioxidant , philosophy , gene , nad+ kinase , downregulation and upregulation , epistemology
A votre Santé! The mechanism by which resveratrol, a hydroxystilbenoid polyphenol found in grapes and present in wine, exerts antiaging metabolic benefits has been uncovered. Chung and co‐workers have found that it works by inhibiting cAMP phosphodiesterases, thus triggering a signaling cascade that leads to the possible activation of the mammalian enzyme sirtuin 1.