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Near‐Infrared Emitting Radioactive Gold Nanoparticles with Molecular Pharmacokinetics
Author(s) -
Zhou Chen,
Hao Guiyang,
Thomas Patrick,
Liu Jinbin,
Yu Mengxiao,
Sun Shasha,
Öz Orhan K.,
Sun Xiankai,
Zheng Jie
Publication year - 2012
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201203031
Subject(s) - nanoprobe , nanoparticle , colloidal gold , infrared , nanotechnology , fluorescence , molecular imaging , chemistry , radiochemistry , materials science , optics , physics , microbiology and biotechnology , in vivo , biology
A molecular nanoprobe : Glutathione‐coated near‐infrared‐emitting radioactive gold nanoparticles have been synthezised and behave like small‐molecule contrast agents in pharmocokinetics. These nanoparticles show a rapid distribution half‐life, a desirable elimination half‐life, and hold promise for single‐photon emission computed tomography (SPECT) and fluorescence imaging (see picture).