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Catalytic Asymmetric Synthesis of Spirooxindoles by a Mannich‐Type Reaction of Isothiocyanato Oxindoles
Author(s) -
Kato Shota,
Yoshino Tatsuhiko,
Shibasaki Masakatsu,
Kanai Motomu,
Matsunaga Shigeki
Publication year - 2012
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201203005
Subject(s) - oxindole , imidazolidine , catalysis , adduct , chemistry , combinatorial chemistry , schiff base , organic chemistry , stereochemistry
Easy access : A strontium/Schiff base complex as catalyst for the title reaction provided straightforward access to enantiomerically enriched spiro[imidazolidine‐4,3′‐oxindole] compounds, as well as a spiro[imidazoline‐4,3′‐oxindole] through a two‐step conversion from the Mannich adduct.
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