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Supramolecular Peptide Amphiphile Vesicles through Host–Guest Complexation
Author(s) -
Jiao Dezhi,
Geng Jin,
Loh Xian Jun,
Das Debapratim,
Lee TungChun,
Scherman Oren A.
Publication year - 2012
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201202947
Subject(s) - supramolecular chemistry , amphiphile , vesicle , pyrene , viologen , chemistry , peptide , cytotoxicity , in vitro , fluorescence , combinatorial chemistry , biophysics , organic chemistry , biochemistry , copolymer , molecule , membrane , biology , polymer , physics , quantum mechanics
Tricky triggering : Supramolecular peptide amphiphiles were prepared by host–guest complexation of pyrene‐labeled peptides and viologen lipid with cucurbit[8]uril. They self‐assemble into vesicles, which are responsive to a variety of external triggers. Both “switching on” and “switching off” of fluoresence and cytotoxicity is demonstrated in vitro.