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On the Biological Properties of Alkynyl Phosphine Gold(I) Complexes
Author(s) -
Meyer Andreas,
Bagowski Christoph P.,
Kokoschka Malte,
Stefanopoulou Maria,
Alborzinia Hamed,
Can Suzan,
Vlecken Danielle H.,
Sheldrick William S.,
Wölfl Stefan,
Ott Ingo
Publication year - 2012
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201202939
Subject(s) - thioredoxin reductase , phosphine , chemistry , zebrafish , ribonucleotide reductase , thioredoxin , biochemistry , computational biology , enzyme , biology , protein subunit , catalysis , gene
Golden times for metal‐based drugs? Alkynyl triphenylphosphine gold(I) complexes display interesting biological properties and show high potential for future drug development. They are strong inhibitors of the enzyme thioredoxin reductase, trigger antiproliferative effects in tumor cells, and influence tumor cell metabolism, mitochondrial respiration, and angiogenesis in zebrafish embryos.