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Conjugation of Transferrin to Azide‐Modified CdSe/ZnS Core–Shell Quantum Dots using Cyclooctyne Click Chemistry
Author(s) -
Schieber Christine,
Bestetti Alessandra,
Lim Jet Phey,
Ryan Anneke D.,
Nguyen TichLam,
Eldridge Robert,
White Anthony R.,
Gleeson Paul A.,
Donnelly Paul S.,
Williams Spencer J.,
Mulvaney Paul
Publication year - 2012
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201202876
Subject(s) - quantum dot , azide , click chemistry , biomolecule , chemistry , cycloaddition , bifunctional , conjugated system , linker , transferrin , hela , nanotechnology , materials science , combinatorial chemistry , polymer , organic chemistry , catalysis , biochemistry , cell , computer science , operating system
Twinkle twinkle quantum dot : Conjugation of biomolecules to azide‐modified quantum dots (QDs) through a bifunctional linker, using strain‐promoted azide–alkyne cycloaddition with the QD and a squaramide linkage to the biomolecule (see scheme). Transferrin‐conjugated QDs were internalized by transferrin‐receptor expressing HeLa cells.