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Diastereodivergent De‐epimerization in Catalytic Asymmetric Allylic Alkylation
Author(s) -
Audisio Davide,
Luparia Marco,
Oliveira Maria Teresa,
Klütt Dina,
Maulide Nuno
Publication year - 2012
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201202853
Subject(s) - diastereomer , epimer , tsuji–trost reaction , selectivity , chemistry , allylic rearrangement , alkylation , stereochemistry , ligand (biochemistry) , catalysis , organic chemistry , receptor , biochemistry
Diastereomers made to order : In an unprecedented ligand‐controlled process a racemic mixture of four stereoisomers can be converted with high selectivity into each one of the diastereomers of the product, at will (see scheme). The mechanism of this deracemization of epimers, that is, a de‐epimerization, was also studied.