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Straightforward Acid‐Catalyzed Synthesis of Pyrrolyldipyrromethenes
Author(s) -
Yu Changjiang,
Jiao Lijuan,
Tan Xujun,
Wang Jun,
Xu Yajun,
Wu Yangchun,
Yang Gaosheng,
Wang Zhaoyun,
Hao Erhong
Publication year - 2012
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201202850
Subject(s) - isoindole , pyrrole , indole test , protonation , catalysis , chemistry , nucleophilic substitution , nucleophile , combinatorial chemistry , medicinal chemistry , organic chemistry , ion
Three for one : Pyrrolyldipyrromethenes having different functional groups were efficiently synthesized from POCl 3 ‐promoted condensations between 5‐chloro‐2‐formylpyrrole or isoindole derivatives and suitable pyrrole or indole fragments through a novel nucleophilic aromatic substitution of the initially formed protonated azafulvene rings.