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Iron‐Catalyzed Alkyl–Alkyl Suzuki–Miyaura Coupling
Author(s) -
Hatakeyama Takuji,
Hashimoto Toru,
Kathriarachchi Kalum K. A. D. S.,
Zenmyo Takeshi,
Seike Hirofumi,
Nakamura Masaharu
Publication year - 2012
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201202797
Subject(s) - xantphos , alkyl , catalysis , halide , chemistry , organic chemistry , primary (astronomy) , coupling (piping) , polymer chemistry , combinatorial chemistry , aryl , materials science , physics , astronomy , metallurgy
Chemoselective Suzuki–Miyaura coupling of primary and secondary alkyl halides is realized by using an iron/Xantphos catalyst. Primary and secondary alkyl bromides undergo the reaction to give the coupling products in good yields. Application to the synthesis of long‐chain fatty acid derivatives is also described (see scheme).