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A Highly Charged Voltage‐Sensor Helix Spontaneously Translocates across Membranes
Author(s) -
He Jing,
Hristova Kalina,
Wimley William C.
Publication year - 2012
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201202741
Subject(s) - membrane , gating , helix (gastropod) , voltage , biophysics , chemistry , membrane potential , potassium channel , materials science , chemical physics , biochemistry , biology , electrical engineering , engineering , ecology , snail
Moving freely : A recent model for voltage gating of potassium channels proposed that the four arginine residues of the voltage‐sensing S4 helix (left) are in direct contact with the membrane lipids and move into the hydrocarbon core of the membrane during gating. It is demonstrated that the physical properties of the isolated S4 sequence (right) are sufficient to allow it to freely translocate across synthetic membranes.