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(Bio)Molecular Surface Patterning by Phototriggered Oxime Ligation
Author(s) -
Pauloehrl Thomas,
Delaittre Guillaume,
Bruns Michael,
Meißler Maria,
Börner Hans G.,
Bastmeyer Martin,
BarnerKowollik Christopher
Publication year - 2012
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201202684
Subject(s) - oxime , ligation , computer science , aldehyde , chemistry , mass spectrometry , information retrieval , combinatorial chemistry , nanotechnology , materials science , medicinal chemistry , chromatography , organic chemistry , microbiology and biotechnology , biology , catalysis
Making light work of ligation : A novel method utilizes light for oxime ligation chemistry. A quantitative, low‐energy photodeprotection generates aldehyde, which subsequently reacts with aminooxy moieties. The spatial control allows patterning on surfaces (see scheme) with a fluoro marker and GRGSGR peptide, and can be imaged by time‐of‐flight secondary‐ion mass spectrometry.