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A Molecular Translator that Acts by Binding‐Induced DNA Strand Displacement for a Homogeneous Protein Assay
Author(s) -
Li Feng,
Zhang Hongquan,
Lai Chong,
Li XingFang,
Le X. Chris
Publication year - 2012
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201202677
Subject(s) - dna , translation (biology) , homogeneous , computational biology , displacement (psychology) , computer science , molecular machine , chemistry , nanotechnology , microbiology and biotechnology , biophysics , biology , physics , genetics , biochemistry , gene , materials science , messenger rna , thermodynamics , psychology , psychotherapist
Protein in, DNA out : A “binding‐induced molecular translator” (see picture) is able to convert an input target protein into an output DNA that can be readily detected and potentially be used to assemble DNA nanodevices. Successful molecular translation is mediated by binding‐induced DNA assembly on a gold nanoparticle (AuNP) scaffold, thereby achieving efficient target‐dependent strand displacement.