Mechanism and Stem‐Cell Activity of 5‐Carboxycytosine Decarboxylation Determined by Isotope Tracing | Zendy

Schiesser Stefan | Zendy; Hackner Benjamin | Zendy; Pfaffeneder Toni | Zendy; Müller Markus | Zendy; Hagemeier Christian | Zendy; Truss Matthias | Zendy; Carell Thomas | Zendy

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Mechanism and Stem‐Cell Activity of 5‐Carboxycytosine Decarboxylation Determined by Isotope Tracing

Author(s) -

Schiesser Stefan,

Hackner Benjamin,

Pfaffeneder Toni,

Müller Markus,

Hagemeier Christian,

Truss Matthias,

Carell Thomas

Publication year - 2012

Publication title -

angewandte chemie international edition

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 5.831

H-Index - 550

eISSN - 1521-3773

pISSN - 1433-7851

DOI - 10.1002/anie.201202583

Subject(s) - decarboxylation , epigenetics , mechanism (biology) , kinetic isotope effect , chemistry , tracing , nucleophile , isotope , oxidative decarboxylation , biology , stereochemistry , biochemistry , physics , computer science , gene , enzyme , deuterium , catalysis , nuclear physics , operating system , quantum mechanics

Eraserhead : Stem cells seem to erase epigenetic information by decarboxylation of the newly discovered epigenetic base 5‐carboxycytosine (caC; see picture). This reaction is likely to involve a nucleophilic attack of the C5C6 double bond.

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