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Mechanism and Stem‐Cell Activity of 5‐Carboxycytosine Decarboxylation Determined by Isotope Tracing
Author(s) -
Schiesser Stefan,
Hackner Benjamin,
Pfaffeneder Toni,
Müller Markus,
Hagemeier Christian,
Truss Matthias,
Carell Thomas
Publication year - 2012
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201202583
Subject(s) - decarboxylation , epigenetics , mechanism (biology) , kinetic isotope effect , chemistry , tracing , nucleophile , isotope , oxidative decarboxylation , biology , stereochemistry , biochemistry , physics , computer science , gene , enzyme , deuterium , catalysis , nuclear physics , operating system , quantum mechanics
Eraserhead : Stem cells seem to erase epigenetic information by decarboxylation of the newly discovered epigenetic base 5‐carboxycytosine (caC; see picture). This reaction is likely to involve a nucleophilic attack of the C5C6 double bond.