Premium
Sialyl Lewis x : A “Pre‐Organized Water Oligomer”?
Author(s) -
Binder Florian P. C.,
Lemme Katrin,
Preston Roland C.,
Ernst Beat
Publication year - 2012
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201202555
Subject(s) - oligomer , chemistry , polymer chemistry
Organized and released : Sialyl Lewis x (sLe x ) represents a “pre‐organized water oligomer”, that is, a surrogate for clustered water molecules attached to a scaffold. The impetus for sLe x binding to E‐selectin is shown to be the high degree of pre‐organization allowing an array of directed hydrogen bonds, and the entropic benefit of the release of water molecules from the large binding interface to bulk water (see picture).