Synthesis of Enantioenriched Triarylmethanes by Stereospecific Cross‐Coupling Reactions | Zendy

Taylor Buck L. H. | Zendy; Harris Michael R. | Zendy; Jarvo Elizabeth R. | Zendy

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Synthesis of Enantioenriched Triarylmethanes by Stereospecific Cross‐Coupling Reactions

Author(s) -

Taylor Buck L. H.,

Harris Michael R.,

Jarvo Elizabeth R.

Publication year - 2012

Publication title -

angewandte chemie international edition

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 5.831

H-Index - 550

eISSN - 1521-3773

pISSN - 1433-7851

DOI - 10.1002/anie.201202527

Subject(s) - stereospecificity , inversion (geology) , aryl , chemistry , reagent , combinatorial chemistry , coupling reaction , stereochemistry , enantioselective synthesis , catalysis , organic chemistry , paleontology , alkyl , structural basin , biology

Coupling with inversion : Chiral diarylmethanol derivatives undergo a stereospecific nickel‐catalyzed cross‐coupling reaction with aryl Grignard reagents (see scheme). The reaction proceeds with inversion of configuration and high enantiospecificity. The method has been applied to the asymmetric synthesis of a triarylmethane‐based anti‐cancer compound.

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