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Synthesis of Enantioenriched Triarylmethanes by Stereospecific Cross‐Coupling Reactions
Author(s) -
Taylor Buck L. H.,
Harris Michael R.,
Jarvo Elizabeth R.
Publication year - 2012
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201202527
Subject(s) - stereospecificity , inversion (geology) , aryl , chemistry , reagent , combinatorial chemistry , coupling reaction , stereochemistry , enantioselective synthesis , catalysis , organic chemistry , paleontology , alkyl , structural basin , biology
Coupling with inversion : Chiral diarylmethanol derivatives undergo a stereospecific nickel‐catalyzed cross‐coupling reaction with aryl Grignard reagents (see scheme). The reaction proceeds with inversion of configuration and high enantiospecificity. The method has been applied to the asymmetric synthesis of a triarylmethane‐based anti‐cancer compound.