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Minimally Invasive Mutagenesis Gives Rise to a Biosynthetic Polyketide Library
Author(s) -
Kushnir Susanna,
Sundermann Uschi,
Yahiaoui Samir,
Brockmeyer Andreas,
Janning Petra,
Schulz Frank
Publication year - 2012
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201202438
Subject(s) - mutagenesis , polyketide , chemistry , computational biology , bacteria , combinatorial chemistry , biochemistry , stereochemistry , biosynthesis , biology , mutation , genetics , gene
Not in the public domain : Site‐directed mutagenesis of megasynthases was the key to the generation of a library of polyketides in bacteria. Redox derivatizations are used to change the bioactivity profile of the compounds.