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Cephalosporin‐3′‐diazeniumdiolates: Targeted NO‐Donor Prodrugs for Dispersing Bacterial Biofilms
Author(s) -
Barraud Nicolas,
Kardak Bharat G.,
Yepuri Nageshwar R.,
Howlin Robert P.,
Webb Jeremy S.,
Faust Saul N.,
Kjelleberg Staffan,
Rice Scott A.,
Kelso Michael J.
Publication year - 2012
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201202414
Subject(s) - biofilm , cephalosporin , prodrug , microbiology and biotechnology , antibiotics , chemistry , cephalosporin antibiotic , bacteria , biology , biochemistry , genetics
Just say NO to biofilms : NO‐donors are used to disperse a bacterial biofilm so that co‐administered antibiotics will kill the more susceptible unattached cells. The chemically stable cephalosporin‐3′‐diazeniumdiolate NO‐donor prodrug (see scheme) is activated by bacterial β‐lactamases and facilitates this two‐step biofilm erradication.