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Reconfigurable Three‐Dimensional DNA Nanostructures for the Construction of Intracellular Logic Sensors
Author(s) -
Pei Hao,
Liang Le,
Yao Guangbao,
Li Jiang,
Huang Qing,
Fan Chunhai
Publication year - 2012
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201202356
Subject(s) - logic gate , adder , xor gate , computer science , dna , förster resonance energy transfer , and gate , nanotechnology , theoretical computer science , algorithm , cmos , physics , electronic engineering , biology , engineering , materials science , genetics , quantum mechanics , fluorescence
Right out of the (logic) gate : Logic gates made from 3D DNA nanotetrahedra were constructed that are responsive to various ions, small molecules, and short strands of DNA. By including dynamic sequences in one or more edges of the tetrahedra, a FRET signal can be generated in the manner of AND, OR, XOR, and INH logic gates, as well as a half‐adder circuit (see scheme). These DNA logic gates were also applied to intracellular detection of ATP.