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Enantioselective β‐Arylation of Ketones Enabled by Lithiation/Borylation/1,4‐Addition Sequence Under Flow Conditions
Author(s) -
Shu Wei,
Buchwald Stephen L.
Publication year - 2012
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201202221
Subject(s) - borylation , sequence (biology) , enantioselective synthesis , rhodium , aryl , combinatorial chemistry , continuous flow , chemistry , computer science , catalysis , organic chemistry , engineering , biochemical engineering , biochemistry , alkyl
The first multistep asymmetric catalysis in flow has been realized using a lithiation/borylation/rhodium‐catalyzed 1,4‐addition sequence. The three‐step sequence starts from readily available and inexpensive aryl bromides, affording β‐arylated ketones in good yields with high levels of enantioselectivity.