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Cover Picture: Discovery and Target Identification of an Antiproliferative Agent in Live Cells Using Fluorescence Difference in Two‐Dimensional Gel Electrophoresis (Angew. Chem. Int. Ed. 22/2012)
Author(s) -
Park Jongmin,
Oh Sangmi,
Park Seung Bum
Publication year - 2012
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Reports
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201202174
Subject(s) - fluorescence , cover (algebra) , gel electrophoresis , identification (biology) , int , electrophoresis , chemistry , biophysics , microbiology and biotechnology , computational biology , biochemistry , biology , computer science , physics , botany , optics , mechanical engineering , engineering , operating system
Target identification is the crown jewel of chemical biology. In their Communication on page 5447 ff., S. B. Park et al. have developed a new target identification method, fluorescence difference in two‐dimensional gel electrophoresis (FITGE), to observe the interactions between proteins and small molecules in an intact cellular environment. FITGE successfully identifies protein differentiation between specific and nonspecific binding of photoaffinity probes.