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Enantioselective Rhodium‐Catalyzed Addition of Potassium Alkenyltrifluoroborates to Cyclic Imines
Author(s) -
Luo Yunfei,
Carnell Andrew J.,
Lam Hon Wai
Publication year - 2012
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201202136
Subject(s) - rhodium , enantioselective synthesis , alkene , catalysis , aryl , chemistry , potassium , organic chemistry , combinatorial chemistry , nickel , medicinal chemistry , alkyl
Fixed : Cyclic imines, in which the CN bond is constrained in the Z geometry, have been identified as highly effective substrates for enantioselective rhodium‐catalyzed additions of potassium alkenyltrifluoroborates. Not only is the alkene in the products a useful functional handle for subsequent manipulations, products containing aryl sulfamates may be employed in nickel‐catalyzed Suzuki–Miyaura and Kumada coupling reactions to generate further compounds of interest.