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Using an Electrical Potential to Reversibly Switch Surfaces between Two States for Dynamically Controlling Cell Adhesion
Author(s) -
Ng Cheuk Chi Albert,
Magenau Astrid,
Ngalim Siti Hawa,
Ciampi Simone,
Chockalingham Muthukumar,
Harper Jason Brian,
Gaus Katharina,
Gooding John Justin
Publication year - 2012
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201202118
Subject(s) - adhesion , cell adhesion , molecule , peptide , biofouling , cell adhesion molecule , nanotechnology , biophysics , materials science , chemistry , microbiology and biotechnology , biochemistry , membrane , composite material , biology , organic chemistry
Smart surfaces presenting both antifouling molecules with a charged functional group at their distal end, and molecules that are terminated by RGD peptides for cell adhesion, were fabricated and characterized (see picture). By applying potentials of +300 or −300 mV, the surfaces could be dynamically switched to make the peptide accessible or inaccessible to cells.