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Cover Picture: Chemical Protein Synthesis by Chemoselective α‐Ketoacid–Hydroxylamine (KAHA) Ligations with 5‐Oxaproline (Angew. Chem. Int. Ed. 21/2012)
Author(s) -
Pattabiraman Vijaya R.,
Ogunkoya Ayodele O.,
Bode Jeffrey W.
Publication year - 2012
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Reports
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201202064
Subject(s) - hydroxylamine , chemistry , int , combinatorial chemistry , amide , peptide bond , protein biosynthesis , stereochemistry , biochemistry , amino acid , operating system , computer science
Chemoselective ligations of two unprotected protein segments that give a native amide bond are valued reactions for the synthesis of proteins. In their Communication on page 5114 ff., J. W. Bode et al. show that the α‐ketoacid—hydroxylamine (KAHA) ligation with 5‐oxaproline is an efficient reaction for the synthesis of proteins with unprotected protein segments in aqueous buffers. Prokaryotic ubiquitin‐like protein and probable cold shock protein A have been synthesized.