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Peptide‐Mediated Blood–Brain Barrier Transport of Polymersomes
Author(s) -
Georgieva Julia V.,
Brinkhuis René P.,
Stojanov Katica,
Weijers Carel A. G. M.,
Zuilhof Han,
Rutjes Floris P. J. T.,
Hoekstra Dick,
van Hest Jan C. M.,
Zuhorn Inge S.
Publication year - 2012
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201202001
Subject(s) - polymersome , nanocarriers , peptide , blood–brain barrier , vesicle , in vitro , in vivo , chemistry , computational biology , biochemistry , nanotechnology , microbiology and biotechnology , biology , neuroscience , drug delivery , membrane , genetics , materials science , central nervous system , organic chemistry , copolymer , amphiphile , polymer
A polymeric nanocarrier : Polymersomes tagged with a dodecamer peptide that recognizes gangliosides GM1 and GT1b are shown to cross the blood–brain barrier, both in an in vitro model and in vivo (see picture). The combination of polymeric vesicles with a small GM1‐binding peptide and GM1/GT1b gangliosides as targeting sites for blood–brain barrier transport is unprecedented.