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Nitrene Chemistry in Organic Synthesis: Still in Its Infancy?
Author(s) -
Dequirez Geoffroy,
Pons Valérie,
Dauban Philippe
Publication year - 2012
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201201945
Subject(s) - nitrene , amination , chemistry , organic synthesis , scope (computer science) , combinatorial chemistry , organic chemistry , reactive intermediate , biochemical engineering , catalysis , nanotechnology , materials science , computer science , engineering , programming language
Abstract The element nitrogen is essential to life. Considerable attention is thus paid to the development of synthetic methods for its introduction into molecules. Nitrenes, long regarded as highly reactive but poorly selective species, have recently emerged as useful tools for the formation of CN bonds. Practical metal‐catalyzed protocols are now available for the preparation of amines through either the aziridination of alkenes or the CH amination of alkanes. Recent results highlighted in this Minireview suggest that synthetic nitrene chemistry is maturing with a wider scope not limited to these two reactions.