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A Catalytic Asymmetric Ugi‐type Reaction With Acyclic Azomethine Imines
Author(s) -
Hashimoto Takuya,
Kimura Hidenori,
Kawamata Yu,
Maruoka Keiji
Publication year - 2012
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201201905
Subject(s) - catalysis , electrophile , imine , ugi reaction , chemistry , amine gas treating , enantioselective synthesis , combinatorial chemistry , stereochemistry , organic chemistry , isocyanide
An unconventional Ugi : A catalytic asymmetric Ugi‐type reaction can be realized by use of N ′‐alkylbenzohydrazide, instead of a conventional amine, in the presence of an axially chiral dicarboxylic acid. The reaction proceeds through a key acyclic azomethine imine intermediate, which has recently emerged as a promising electrophile in asymmetric catalysis.