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Chemoselective Ligation of Sulfinic Acids with Aryl‐Nitroso Compounds
Author(s) -
Lo Conte Mauro,
Carroll Kate S.
Publication year - 2012
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201201812
Subject(s) - sulfinic acid , chemistry , sulfonamide , aryl , combinatorial chemistry , organic chemistry , alkyl
Making a comeback : The inefficient condensation of sulfinic acid and aryl nitroso compounds has been transformed into a chemoselective process that converts sulfinic acid into stable cyclic sulfonamide analogues (see scheme). This ligation proceeds rapidly under aqueous conditions in high yield, and lays the groundwork for the development of sulfinic acid detection methods in biological systems.