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Double Cyclization/Aryl Migration Across an Alkyne Bond Enabled by Organoboryl and Diarylplatinum Groups
Author(s) -
Sun Christina,
Hudson Zachary M.,
Chen Leanne D.,
Wang Suning
Publication year - 2012
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201201781
Subject(s) - alkyne , aryl , transformation (genetics) , group (periodic table) , chemistry , stereochemistry , medicinal chemistry , organic chemistry , catalysis , biochemistry , alkyl , gene
Synergy between metals : Diarylacetylenes 1 , containing both a boryl (BMes 2 ) group and a diarylplatinum group, undergo a transformation involving a double metallocyclization/aryl migration to give tetracycles 2 in high diastereoselectivity (see scheme). This remarkable transformation is enabled by the synergistic interplay of the boryl and the diarylplatinum group.