(IscS‐IscU) 2  Complex Structures Provide Insights into Fe 2 S 2  Biogenesis and Transfer | Zendy

Marii Elodie N. | Zendy; de Oliveira Jaim S. | Zendy; Nicolet Yvain | Zendy; Raulfs Estella C. | Zendy; Amara Patricia | Zendy; Dean Dennis R. | Zendy; FontecillaCamps Juan C. | Zendy

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(IscS‐IscU) 2 Complex Structures Provide Insights into Fe 2 S 2 Biogenesis and Transfer

Author(s) -

Marii Elodie N.,

de Oliveira Jaim S.,

Nicolet Yvain,

Raulfs Estella C.,

Amara Patricia,

Dean Dennis R.,

FontecillaCamps Juan C.

Publication year - 2012

Publication title -

angewandte chemie international edition

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 5.831

H-Index - 550

eISSN - 1521-3773

pISSN - 1433-7851

DOI - 10.1002/anie.201201708

Subject(s) - biogenesis , chemistry , computational biology , biology , biochemistry , gene

The center of attention : IscS cysteine desulfurases and IscU scaffolds are involved in biological iron–sulfur cluster assembly. The X‐ray structure of an anaerobically produced, mutated (Fe 2 S 2 ‐(IscS‐IscU D35A )) 2 complex reveals a cluster coordinated by three IscU cysteines and the IscS active cysteine (see picture). In air‐exposed crystals the cluster is oxidized to an Fe 2 S–S center; D35 is essential for complex dissociation.

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