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Preparation of Alkylmagnesium Reagents from Alkenes through Hydroboration and Boron–Magnesium Exchange
Author(s) -
Reichle Markus A.,
Breit Bernhard
Publication year - 2012
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201201704
Subject(s) - hydroboration , reagent , chemistry , magnesium , boron , alkylation , organic chemistry , combinatorial chemistry , catalysis
Tolerant : Alkylmagnesium reagents can be synthesized from alkenes through a sequence of hydroboration and subsequent boron–magnesium exchange using a method that tolerates different functional groups (see scheme). The resulting alkylmagnesium reagents can be used in carbon–carbon bond forming reactions, such as alkylation reactions or transition‐metal‐catalyzed cross‐coupling reactions.