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Industrial Applications of the Diels–Alder Reaction
Author(s) -
Funel JacquesAlexis,
Abele Stefan
Publication year - 2013
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201201636
Subject(s) - diels–alder reaction , alder , process (computing) , focus (optics) , perspective (graphical) , agrochemical , scale (ratio) , biochemical engineering , chemistry , computer science , organic chemistry , nanotechnology , combinatorial chemistry , engineering , materials science , artificial intelligence , geography , biology , archaeology , catalysis , ecology , agriculture , physics , programming language , cartography , optics
The Diels–Alder reaction is one of the most popular transformations for organic chemists to generate molecular complexity efficiently. Surprisingly, little is known about its industrial application for the synthesis of pharmacologically active ingredients, agrochemicals, and flavors and fragrances. This Review highlights selected examples, with a focus on large‐scale applications (>1 kg) from a process research and development perspective.