Premium
Boronic Acid Catalysis as a Mild and Versatile Strategy for Direct Carbo‐ and Heterocyclizations of Free Allylic Alcohols
Author(s) -
Zheng Hongchao,
Ghanbari Sina,
Nakamura Shinji,
Hall Dennis G.
Publication year - 2012
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201201620
Subject(s) - chemistry , catalysis , boronic acid , allylic rearrangement , halide , organic chemistry , combinatorial chemistry
BAC to the future : Boronic acid catalysis (BAC) was applied to the direct activation of alcohols leading to the preparation of carbocycles (see scheme), benzofurans, tetrahydrofurans, pyrrolidines, pyrans, piperidines, and various polycyclic compounds. The reactions proceed under mild conditions that circumvent the use of reactive leaving groups like halides.