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Copper‐Mediated and Copper‐Catalyzed Cross‐Coupling of Indoles and 1,3‐Azoles: Double CH Activation
Author(s) -
Nishino Mayuko,
Hirano Koji,
Satoh Tetsuya,
Miura Masahiro
Publication year - 2012
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201201491
Subject(s) - copper , indole test , catalysis , ideal (ethics) , coupling (piping) , combinatorial chemistry , chemistry , bronze , computer science , stereochemistry , materials science , organic chemistry , metallurgy , political science , law
A new bronze age : The described copper‐mediated cross‐coupling with double CH activation can provide a convergent access to indole‐containing biheteroaryls that are of high interest in pharmaceutical and medicinal chemistry. In this strategy an easily attachable and detachable 2‐pyrimidyl directing group is used. Moreover, a variant that is catalytic in copper is achieved by using atmospheric oxygen as an ideal co‐oxidant (see scheme).