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Reaction Discovery by Using a Sandwich Immunoassay
Author(s) -
Quinton Julia,
Kolodych Sergii,
Chaumonet Ma,
Bevilacqua Valentina,
Nevers MarieClaire,
Volland Hervé,
Gabillet Sandra,
Thuéry Pierre,
Crémi Christophe,
Taran Frédéric
Publication year - 2012
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201201451
Subject(s) - thiazole , combinatorial chemistry , coupling reaction , computer science , chemistry , immunoassay , organic chemistry , catalysis , medicine , antibody , immunology
Mmm, a reaction sandwich… Using an immunoassay‐based technique able to monitor any kind of cross‐coupling reaction, a systematic and rapid evaluation of a large panel of random reactions was carried out. This approach led to the discovery of two new copper‐promoted reactions: a desulfurization reaction of thioureas leading to isoureas and a cyclization reaction leading to thiazole derivatives from alkynes and N‐ hydroxy thioureas.