Reaction Discovery by Using a Sandwich Immunoassay | Zendy

Quinton Julia | Zendy; Kolodych Sergii | Zendy; Chaumonet Ma | Zendy; Bevilacqua Valentina | Zendy; Nevers MarieClaire | Zendy; Volland Hervé | Zendy; Gabillet Sandra | Zendy; Thuéry Pierre | Zendy; Crémi Christophe | Zendy; Taran Frédéric | Zendy

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Reaction Discovery by Using a Sandwich Immunoassay

Author(s) -

Quinton Julia,

Kolodych Sergii,

Chaumonet Ma,

Bevilacqua Valentina,

Nevers MarieClaire,

Volland Hervé,

Gabillet Sandra,

Thuéry Pierre,

Crémi Christophe,

Taran Frédéric

Publication year - 2012

Publication title -

angewandte chemie international edition

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 5.831

H-Index - 550

eISSN - 1521-3773

pISSN - 1433-7851

DOI - 10.1002/anie.201201451

Subject(s) - thiazole , combinatorial chemistry , coupling reaction , computer science , chemistry , immunoassay , organic chemistry , catalysis , medicine , antibody , immunology

Mmm, a reaction sandwich… Using an immunoassay‐based technique able to monitor any kind of cross‐coupling reaction, a systematic and rapid evaluation of a large panel of random reactions was carried out. This approach led to the discovery of two new copper‐promoted reactions: a desulfurization reaction of thioureas leading to isoureas and a cyclization reaction leading to thiazole derivatives from alkynes and N‐ hydroxy thioureas.

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