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Turning “On” and “Off” a Pyridoxal 5′‐Phosphate Mimic Using Light
Author(s) -
Wilson Danielle,
Branda Neil R.
Publication year - 2012
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201201447
Subject(s) - racemization , pyridinium , pyridoxal , pyridoxal phosphate , cofactor , aldehyde , chemistry , pyridoxal 5 phosphate , phosphate , catalysis , stereochemistry , combinatorial chemistry , enzyme , biochemistry , organic chemistry
Light is used to toggle a photoresponsive mimic of the cofactor pyridoxal phosphate between two isomers, where only one of them can catalyze the racemization of an amino acid. The system is based on creating and breaking electronic communication between the two catalyst components, i.e., an aldehyde and a pyridinium cation.