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Protein Expression, Aggregation, and Triggered Release from Polymersomes as Artificial Cell‐like Structures
Author(s) -
Martino Chiara,
Kim ShinHyun,
Horsfall Louise,
Abbaspourrad Alireza,
Rosser Susan J.,
Cooper Jonathan,
Weitz David A.
Publication year - 2012
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201201443
Subject(s) - polymersome , cytoskeleton , biocompatible material , artificial cell , osmotic shock , microbiology and biotechnology , protein expression , chemistry , biophysics , amino acid , lysis , mreb , nanotechnology , cell , materials science , biochemistry , copolymer , biology , membrane , polymer , amphiphile , biomedical engineering , engineering , gene , organic chemistry
Bringing droplets to life : A cytoskeletal protein (red dots, see scheme) is expressed in artificial cells composed of biocompatible polymersomes, which encapsulate expression machinery and amino acid building blocks. Release of the expressed proteins can be triggered by a negative osmotic shock.