N Alkylation of Tosylamides Using Esters as Primary and Tertiary Alkyl Sources: Mediated by Hydrosilanes Activated by a Ruthenium Catalyst | Zendy

Nishikata Takashi | Zendy; Nagashima Hideo | Zendy

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N Alkylation of Tosylamides Using Esters as Primary and Tertiary Alkyl Sources: Mediated by Hydrosilanes Activated by a Ruthenium Catalyst

Author(s) -

Nishikata Takashi,

Nagashima Hideo

Publication year - 2012

Publication title -

angewandte chemie international edition

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 5.831

H-Index - 550

eISSN - 1521-3773

pISSN - 1433-7851

DOI - 10.1002/anie.201201426

Subject(s) - ruthenium , alkylation , alkyl , catalysis , chemistry , primary (astronomy) , nitrogen atom , medicinal chemistry , organic chemistry , physics , astronomy

Select your group : Either a primary or tertiary alkyl group can be selectively introduced onto the nitrogen atom of tosylamides in a ruthenium‐catalyzed reaction employing hydrosilanes through a judicious choice in the esters that serve as the alkyl source (see scheme; Ts= 4‐toluenesulfonyl). These N‐alkylation reactions are useful for construction of naturally occurring azacyclic skeletons.

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